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Zifam Asist

  • ENG
  • မြန်မာ

 

Composition

Each ml contains:
Acetylcysteine USP ………….. 200 mg
Water for injections BP ……… q.s.
 

Description

Acetylcysteine is the N-acetyl derivative of cysteine used primarily as a mucolytic agent and as intravenous (I.V.) medication in the management of acetaminophen overdose.
 

Mechanism of Action

Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose.It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Acetylcysteine likely protects the liver by maintaining and restoring the glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite.
 

Indications

This medication is used as an antidote for acetaminophen overdose to prevent life-threatening liver damage.
 

Contraindication

Acetylcysteine is contraindicated in patients with hypersensitivity or previous anaphylactic reaction to acetylcysteine or any component of the preparation.
 

DOSAGE

Pre-Treatment Assessment Following Acute Ingestion:

Obtain a plasma or serum sample to assay for acetaminophen concentration at least 4 hours after ingestion.

If the time of acetaminophen ingestion is unknown:

If the patient presents more than 8 hours after ingestion and the time of acute acetaminophen ingestion is known:

If the patient presents less than 8 hours after ingestion and the time of acute acetaminophen ingestion is known and theacetaminophen concentration is known:

Use the Rumack – Matthewnomogram to determine whether or not to initiate treatment with ZIFAM ASIST INJECTION

 

Warning & Precautions

Monitor, acute flushing and erythema of the skin may occur, usually associated with the loading dose, often resolves spontaneously despite continued infusion.
Monitor for serious anaphylactoid reactions; infusion may be interrupted until treatment of anaphylactoid symptoms has been initiated.


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