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Zifam Dovaspin injection

  • ENG
  • မြန်မာ

 

Zifam Dovaspin InJection

Composition

Each ml contains:

Drotaverine HCl           20 mg

Absolute Alcohol BP  8% v/v

Water for injection BP      q.s.

 

Indications / Uses

Relieves pain caused by smooth muscle spasm.

 

Dosage / Direction for Use

1 to 2 ampoules, IM or SC, 1 to 3 times daily or as directed by the physician

 

Special Precautions

Collapse might have been due to administration in sitting position.

 

Adverse Reactions

The spasmolytic effect of drotaverine hydrochloride develops within minutes without appreciable side effects. It causes no pathological alterations in the tissues of higher animals. No irritable effect on tissue. Embryotoxicity or teratogenic effects were not found.

 

Interactions

Zifam dovaspin is compatible with other drugs.

 

Storage

Store at temperature not more than 30°C. Protect from light.

 

Mechanism of Action

Pharmacology: Drotaverine is an is quinolone derivative that has spasmolytic action on smooth muscle of the coronary, peripheral arteries and urogenital tracts. Its action is due to surface activity by binding to the smooth muscle surface, altering the membrane potential and permeability. Since the protein-binding is lower, its effect develops more rapidly, released slowly and last longer than that of papaverine and perparine. It is completely absorbed, metabolized by the liver and excreted in the bile (50%) and urine (30%). It is several times more effective than papaverine and is better tolerated by humans.

MIMS Class

Antispasmodics

 

ATC Classification

A03AD02 – drotaverine ; Belongs to the class of papaverine and derivatives. Used in the treatment of functional bowel disorders.

 

Presentation / Packing

A carton containing 10 ampoules of 2 ml each.


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