Zifam Dovaspin injection
Zifam Dovaspin InJection
Each ml contains:
Drotaverine HCl 20 mg
Absolute Alcohol BP 8% v/v
Water for injection BP q.s.
Indications / Uses
Relieves pain caused by smooth muscle spasm.
Dosage / Direction for Use
1 to 2 ampoules, IM or SC, 1 to 3 times daily or as directed by the physician
Collapse might have been due to administration in sitting position.
The spasmolytic effect of drotaverine hydrochloride develops within minutes without appreciable side effects. It causes no pathological alterations in the tissues of higher animals. No irritable effect on tissue. Embryotoxicity or teratogenic effects were not found.
Zifam dovaspin is compatible with other drugs.
Store at temperature not more than 30°C. Protect from light.
Mechanism of Action
Pharmacology: Drotaverine is an is quinolone derivative that has spasmolytic action on smooth muscle of the coronary, peripheral arteries and urogenital tracts. Its action is due to surface activity by binding to the smooth muscle surface, altering the membrane potential and permeability. Since the protein-binding is lower, its effect develops more rapidly, released slowly and last longer than that of papaverine and perparine. It is completely absorbed, metabolized by the liver and excreted in the bile (50%) and urine (30%). It is several times more effective than papaverine and is better tolerated by humans.
A03AD02 – drotaverine ; Belongs to the class of papaverine and derivatives. Used in the treatment of functional bowel disorders.
Presentation / Packing
A carton containing 10 ampoules of 2 ml each.