Clopidogrel Hydrogen Sulphate
Film coated tablet 75mg x 10’s x 3 strips
CLOVIX (Clopidogrel Hydrogen Sulphate) is an inhibitor of ADP induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP), binding to its receptor and of the subsequent ADP, mediated activation of the glycoprotein GPIIb/IIIa complex.
Clopidogrel is an inhibitor of platelet aggregation. A variety of drugs that inhibit platelet function have been shown to decrease morbid events in people with established atherosclerotic cardiovascular disease as evidenced by stroke or transient ischemic attacks, myocardial infarction, or need for bypass or angioplasty. This indicates that platelets participate in the initiation and/or evolution of these events and that inhibiting them can reduce the event rate.
CLOVIX (Clopidogrel Hydrogen Sulphate) is indicated for the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
The use of CLOVIX is contraindicated in the following conditions:
- Hypersensitivity to the drug substance or any component of the product
- Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
DOSAGE AND ADMINISTRATION
The recommended dose of CLOVIX is 75mg once daily with or without food. No dosage adjustment is necessary for elderly patients or patients with renal disease.
Special Precaution: Trauma, surgery, or other pathological conditions, ulcer, severe hepatic disease.
Coadministration of clopidogrel with NSAIDs may increase the risk of stomach and intestinal bleeding.
Life Threatening: Bleeding and gastrointestinal hemorrhage.
Others: Serious events include bleeding and gastrointestinal hemorrhage. GI upset, diarrhea, pruritus, headache, dizziness and rashes.
A single oral dose of Clopidogrel at 1500 or 2000mg/kg was lethal to mice and to rats and at 3000 mg/kg to baboons.
Recommendations about Specific Treatment: Based on biological plausibility, platelet transfusion may be appropriate to reverse the pharmacological effects of CLOVIX if quick reversal is required.
Use in Pregnancy and Lactation
Pregnancy Category B. There are no adequate and well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of a human response, CLOVIX should be used during pregnancy only if clearly needed.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and
Safety and effectiveness in the pediatric population have not been established.